CDKL2

Across TCGA patient cohorts, CDKL2 mutation is significantly associated with the RNA expression of many other genes, with 2,263 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDKL2-associated genes across cancer lineages are RNU6-982P, TRIM64EP, and CCT8. Each is linked with CDKL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CDKL2-to-partner and partner-to-CDKL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-982P grouped by CDKL2-low versus CDKL2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDKL2→partner) and Y-score (partner→CDKL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-982P →	+1.021	+7.930	<.001	.008	3	3
CESC	TRIM64EP →	+0.071	+5.969	<.001	.002	3	2
UCEC	CCT8 →	+0.389	+1.847	.007	.009	3	2
UCEC	TYW3 →	+0.448	+3.628	.001	.001	3	2
UCEC	SRP68 →	+0.453	+2.747	<.001	<.001	3	2
UCEC	RMDN1 →	+0.391	+2.290	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,263 associations by consensus.

RNU6-982P by CDKL2 expression — LUAD

Explore this box plot interactively →