CDKL2

Across TCGA cell cohorts, CDKL2 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CDKL2-associated genes across cancer lineages are ANKRD30BL, OR2AJ1, and IAPP. Each is linked with CDKL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDKL2-to-partner and partner-to-CDKL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ANKRD30BL grouped by CDKL2-low versus CDKL2-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDKL2→partner) and Y-score (partner→CDKL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ANKRD30BL →	+0.023	+4.906	<.001	.006	3	1
BLOOD_Lymphoma	OR2AJ1 →	+0.042	+4.867	<.001	.009	3	1
LARGE_INTESTINE	IAPP →	+0.450	+3.617	<.001	.004	3	1
LARGE_INTESTINE	GCM2 →	+0.064	+3.242	<.001	.003	3	1
LARGE_INTESTINE	RASGEF1C →	+0.235	+3.333	.003	.009	3	1
LARGE_INTESTINE	SLC25A31 →	+0.062	+3.115	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

ANKRD30BL by CDKL2 expression — OESOPHAGUS

Explore this box plot interactively →