CDKL1

Across TCGA patient cohorts, CDKL1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDKL1-associated genes across cancer lineages are EGFR_pY1068, EGFR, and eIF4E. Each is linked with CDKL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDKL1-to-partner and partner-to-CDKL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CDKL1-low versus CDKL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDKL1→partner) and Y-score (partner→CDKL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.202	-2.459	.028	.018	3	1
UCEC	EGFR →	-0.176	-1.700	.002	.042	3	1
UCEC	eIF4E →	+0.188	+3.335	.015	.005	3	1
UCEC	ACC1 →	+0.321	+2.183	.016	.033	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.382	+2.469	.041	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.160	-1.700	.009	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

EGFR_pY1068 by CDKL1 expression — UCEC

Explore this box plot interactively →