CDKL1

Across TCGA cell cohorts, CDKL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,419 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible CDKL1-associated GO terms across cancer lineages are Purine ribonucleoside monophosphate metabolic process, GMP metabolic process, and GMP biosynthetic process. Each is linked with CDKL1 in more than 7 cancer types. Because this analysis shows association rather than direction, both CDKL1-to-partner and partner-to-CDKL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Purine ribonucleoside monophosphate metabolic process grouped by CDKL1-low versus CDKL1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CDKL1→partner) and Y-score (partner→CDKL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Purine ribonucleoside monophosphate metabolic process →	+0.083	+1.274	.003	.002	3	8
OESOPHAGUS	GMP metabolic process →	+0.112	+1.310	<.001	.002	3	8
SKIN	GMP biosynthetic process →	+0.110	+1.462	<.001	<.001	3	7
LUNG_SCLC	IMP salvage →	+0.196	+1.289	.002	.008	2	8
BREAST	IMP metabolic process →	+0.126	+1.465	<.001	<.001	3	7
OVARY	Purine ribonucleoside monophosphate biosynthetic process →	+0.106	+1.265	.006	.005	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,419 associations by consensus.

Purine ribonucleoside monophosphate metabolic process by CDKL1 expression — OESOPHAGUS

Explore this box plot interactively →