CDKAL1

Across TCGA pan-cancer cohorts, CDKAL1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CDKAL1 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher CDKAL1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated CDKAL1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and OV show a favorable association.

LSCC, PDAC, and CCRCC are the cancer types where CDKAL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	All	0.974	0.740	.001	37	view →
PDAC	DFS	Quartile	All	0.586	0.900	.001	21	view →
CCRCC	OS	Median	All	0.637	1.000	.003	9	view →
OV	DFS	Median	All	0.874	0.579	.021	4	view →
UCEC	DFS	Median	All	0.856	0.943	.038	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CDKAL1–LSCC (OS)

Open the LSCC breakdown →