CDKAL1

Across TCGA patient cohorts, CDKAL1 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDKAL1-associated genes across cancer lineages are eIF4E, JNK2, and mTOR_pS2448. Each is linked with CDKAL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDKAL1-to-partner and partner-to-CDKAL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CDKAL1-low versus CDKAL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDKAL1→partner) and Y-score (partner→CDKAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.196	+2.820	.006	.001	3	2
UCEC	JNK2 →	+0.204	+1.807	.002	.004	3	2
UCEC	mTOR_pS2448 →	-0.176	-3.794	<.001	<.001	3	2
UCEC	AR →	-0.357	-1.247	.005	.045	3	2
UCEC	Caspase-7-cleavedD198 →	+0.643	+1.505	.001	.034	3	2
UCEC	eEF2 →	+0.391	+3.807	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

eIF4E by CDKAL1 expression — UCEC

Explore this box plot interactively →