CDKAL1

Across TCGA cell cohorts, CDKAL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,587 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CDKAL1-associated GO terms across cancer lineages are Negative regulation of RNA export from nucleus, Negative regulation of nucleobase-containing compound transport, and Establishment of sister chromatid cohesion. Each is linked with CDKAL1 in more than 15 cancer types. Because this analysis shows association rather than direction, both CDKAL1-to-partner and partner-to-CDKAL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of RNA export from nucleus grouped by CDKAL1-low versus CDKAL1-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CDKAL1→partner) and Y-score (partner→CDKAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of RNA export from nucleus →	+0.159	+0.942	.001	.003	2	16
BREAST	Negative regulation of nucleobase-containing compound transport →	+0.151	+0.715	<.001	<.001	3	13
OESOPHAGUS	Establishment of sister chromatid cohesion →	+0.157	+0.605	.003	.007	3	13
PANCREAS	Protein peptidyl-prolyl isomerization →	+0.104	+0.436	<.001	<.001	3	12
SOFT_TISSUE	Protein-DNA complex assembly →	+0.056	+0.514	<.001	<.001	3	11
KIDNEY	Protein modification by small protein removal →	+0.038	+0.713	.002	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,587 associations by consensus.

Negative regulation of RNA export from nucleus by CDKAL1 expression — STOMACH

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