CDKAL1

Across TCGA cell cohorts, CDKAL1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CDKAL1-associated genes across cancer lineages are SERPINA7, OR1E2, and WFDC8. Each is linked with CDKAL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDKAL1-to-partner and partner-to-CDKAL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SERPINA7 grouped by CDKAL1-low versus CDKAL1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDKAL1→partner) and Y-score (partner→CDKAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SERPINA7 →	+0.011	+4.700	.001	.002	3	1
BLOOD_Lymphoma	OR1E2 →	+0.016	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	WFDC8 →	+0.015	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	RNASE8 →	+0.030	+5.209	.001	.005	3	1
LARGE_INTESTINE	LHCGR →	+0.050	+4.467	<.001	.004	3	1
BLOOD_Leukemia	TAS2R7 →	+0.018	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

SERPINA7 by CDKAL1 expression — OVARY

Explore this box plot interactively →