CDK9

Across TCGA patient cohorts, CDK9 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDK9-associated genes across cancer lineages are ERK2, JNK2, and MSH2. Each is linked with CDK9 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDK9-to-partner and partner-to-CDK9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by CDK9-low versus CDK9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK9→partner) and Y-score (partner→CDK9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.202	+3.321	.013	.010	3	1
UCEC	JNK2 →	+0.193	+1.700	.022	.044	3	1
UCEC	MSH2 →	-0.232	-1.700	.017	.044	3	1
UCEC	p70-S6K_pT389 →	-0.171	-3.312	.034	.010	3	1
UCEC	Rad50 →	-0.204	-1.700	.047	.044	2	2
UCEC	STAT3_pY705 →	-0.339	-2.999	.002	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ERK2 by CDK9 expression — UCEC

Explore this box plot interactively →