CDK9

Across TCGA cell cohorts, CDK9 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDK9-associated genes across cancer lineages are FTHL17, COX6A2, and SPIC. Each is linked with CDK9 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDK9-to-partner and partner-to-CDK9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FTHL17 grouped by CDK9-low versus CDK9-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK9→partner) and Y-score (partner→CDK9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FTHL17 →	+0.060	+4.415	<.001	.007	3	1
LARGE_INTESTINE	COX6A2 →	+0.102	+5.022	<.001	.002	3	1
LARGE_INTESTINE	SPIC →	+0.296	+4.095	<.001	.009	3	1
LARGE_INTESTINE	TBC1D21 →	+0.015	+5.022	<.001	.002	3	1
LARGE_INTESTINE	LCE5A →	+0.231	+4.273	<.001	.006	3	1
LARGE_INTESTINE	KRTAP21-2 →	+0.089	+4.930	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

FTHL17 by CDK9 expression — LARGE_INTESTINE

Explore this box plot interactively →