CDK8

Across TCGA patient cohorts, CDK8 RNA expression is significantly associated with the protein abundance of many other proteins, with 17,882 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CDK8-associated proteins across cancer lineages are ZMYM2, HSPH1, and KPNA3. Each is linked with CDK8 in more than 7 cancer types. Because this analysis shows association rather than direction, both CDK8-to-partner and partner-to-CDK8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CDK8 versus ZMYM2 in HNSC, with a Pearson correlation of 0.38.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK8→partner) and Y-score (partner→CDK8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ZMYM2 →	+0.442	+0.695	<.001	<.001	3	8
COAD	HSPH1 →	+0.618	+0.499	<.001	<.001	3	6
BRCA	KPNA3 →	+0.306	+0.426	<.001	<.001	3	6
GBM	ADNP →	+0.327	+0.380	<.001	<.001	3	6
LSCC	XPO5 →	+0.580	+0.541	<.001	<.001	3	5
GBM	HMGB1 →	+0.407	+0.409	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,882 associations by consensus.

CDK8 vs ZMYM2 — HNSC

Explore this scatter interactively →