CDK8

Across TCGA patient cohorts, CDK8 protein abundance is significantly associated with the RNA expression of many other genes, with 11,575 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CDK8-associated genes across cancer lineages are XXYLT1, HROB, and MDC1. Each is linked with CDK8 in more than 3 cancer types. Because this analysis shows association rather than direction, both CDK8-to-partner and partner-to-CDK8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CDK8 versus XXYLT1 in OV, with a Pearson correlation of 0.64.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK8→partner) and Y-score (partner→CDK8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	XXYLT1 →	+1.054	+1.209	<.001	.001	3	4
UCEC	HROB →	+0.774	+0.523	.003	<.001	3	4
UCEC	MDC1 →	+0.662	+0.397	.002	.001	3	4
BRCA	FANCI →	+0.756	+0.669	.001	.001	3	4
UCEC	ARHGAP11B →	+0.855	+0.451	.001	<.001	3	4
HNSC	TTC4P1 →	-0.516	-0.562	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,575 associations by consensus.

CDK8 vs XXYLT1 — OV

Explore this scatter interactively →