CDK8

Across TCGA patient cohorts, CDK8 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDK8-associated genes across cancer lineages are FoxM1, p62 Lck ligand, and ACC1. Each is linked with CDK8 in more than 2 cancer types. Because this analysis shows association rather than direction, both CDK8-to-partner and partner-to-CDK8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by CDK8-low versus CDK8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK8→partner) and Y-score (partner→CDK8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.281	+3.584	.024	.002	3	3
UCEC	p62 Lck ligand →	+0.517	+3.584	<.001	.002	3	2
UCEC	ACC1 →	+0.393	+2.820	.025	.035	3	1
UCEC	Ku80 →	+0.346	+3.598	.002	.001	3	1
UCEC	Notch1 →	+0.203	+2.820	.002	.035	3	1
UCEC	Annexin_VII →	-0.142	-2.459	.034	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

FoxM1 by CDK8 expression — UCEC

Explore this box plot interactively →