CDK8

Across TCGA cell cohorts, CDK8 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,516 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible CDK8-associated GO terms across cancer lineages are snRNA pseudouridine synthesis, Sister chromatid biorientation, and Mitochondrial translational termination. Each is linked with CDK8 in more than 10 cancer types. Because this analysis shows association rather than direction, both CDK8-to-partner and partner-to-CDK8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, snRNA pseudouridine synthesis grouped by CDK8-low versus CDK8-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK8→partner) and Y-score (partner→CDK8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	snRNA pseudouridine synthesis →	+0.056	+0.805	.001	<.001	3	11
OESOPHAGUS	Sister chromatid biorientation →	+0.152	+0.780	<.001	.008	3	11
LUNG_SCLC	Mitochondrial translational termination →	+0.114	+0.720	<.001	.002	3	11
SOFT_TISSUE	Regulation of RNA stability →	+0.080	+1.159	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Cell cycle G1/S phase transition →	+0.065	+0.813	<.001	.004	3	10
OESOPHAGUS	Ribosomal protein import into nucleus →	+0.080	+0.491	.006	.008	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,516 associations by consensus.

snRNA pseudouridine synthesis by CDK8 expression — BREAST

Explore this box plot interactively →