CDK8

Across TCGA cell cohorts, CDK8 mutation is significantly associated with the drug of many other genes, with 24 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDK8-associated genes across cancer lineages are Mirin, Leflunomide, and GSK2801. Each is linked with CDK8 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDK8-to-partner and partner-to-CDK8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mirin grouped by CDK8-low versus CDK8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK8→partner) and Y-score (partner→CDK8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Mirin →	+0.429	+2.646	.023	.047	3	1
LARGE_INTESTINE	Leflunomide →	+0.288	+2.769	.024	.040	3	1
LARGE_INTESTINE	GSK2801 →	+0.370	+2.649	.019	.046	3	1
LARGE_INTESTINE	AGI-6780 →	+0.403	+2.646	.038	.047	3	1
LARGE_INTESTINE	Quizartinib →	+0.450	+2.652	.004	.045	3	1
LARGE_INTESTINE	PF-00299804 →	+0.724	+2.652	.001	.045	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Mirin by CDK8 expression — LARGE_INTESTINE

Explore this box plot interactively →