CDK7

Across TCGA pan-cancer cohorts, CDK7 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CDK7 data layer compared with 26 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher CDK7 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CDK7 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

CCRCC, UCEC, and LUAD are the cancer types where CDK7 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	II,III,IV	0.675	0.956	.001	66	view →
UCEC	DFS	Median	III,IV	1.000	0.386	.002	40	view →
LUAD	DFS	Median	III,IV	0.766	0.291	.003	16	view →
HNSC	OS	Quartile	All	0.410	1.000	.043	14	view →
LSCC	OS	Median	II,III,IV	0.947	0.739	.022	6	view →
PDAC	DFS	Quartile	II,III,IV	0.284	0.526	.036	2	view →
GBM	OS	Quartile	All	0.806	0.917	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CDK7–CCRCC (OS)

Open the CCRCC breakdown →