CDK6

Across TCGA patient cohorts, CDK6 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,345 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible CDK6-associated proteins across cancer lineages are FSCN1, CSPG4, and SERPINB5. Each is linked with CDK6 in more than 4 cancer types. Because this analysis shows association rather than direction, both CDK6-to-partner and partner-to-CDK6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CDK6 versus FSCN1 in BRCA, with a Pearson correlation of 0.62.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK6→partner) and Y-score (partner→CDK6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FSCN1 →	+0.647	+1.104	<.001	<.001	3	5
BRCA	CSPG4 →	+0.526	+0.969	<.001	<.001	3	4
LUAD	SERPINB5 →	+1.747	+0.777	<.001	<.001	3	4
UCEC	PXDN →	+0.489	+0.823	.004	.003	3	3
BRCA	COX17 →	-0.517	-0.763	<.001	<.001	3	3
OV	COX4I1 →	-0.489	-1.287	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,345 associations by consensus.

CDK6 vs FSCN1 — BRCA

Explore this scatter interactively →