CDK6

Across TCGA patient cohorts, CDK6 mutation is significantly associated with the RNA expression of many other genes, with 2,326 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDK6-associated genes across cancer lineages are PLA2G3, CDADC1, and UBE2I. Each is linked with CDK6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDK6-to-partner and partner-to-CDK6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLA2G3 grouped by CDK6-low versus CDK6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK6→partner) and Y-score (partner→CDK6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PLA2G3 →	+0.644	+2.906	.001	.001	3	2
UCEC	CDADC1 →	+0.354	+1.868	<.001	<.001	3	2
UCEC	UBE2I →	+0.305	+2.454	.001	<.001	3	2
UCEC	PLEKHJ1 →	+0.428	+2.032	.002	.001	3	2
UCEC	ZNF330 →	+0.370	+2.136	.001	<.001	3	2
UCEC	NEIL3 →	+0.493	+2.606	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,326 associations by consensus.

PLA2G3 by CDK6 expression — UCEC

Explore this box plot interactively →