CDK6

Across TCGA patient cohorts, CDK6 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDK6-associated genes across cancer lineages are eIF4E, STAT3_pY705, and EGFR_pY1068. Each is linked with CDK6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDK6-to-partner and partner-to-CDK6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CDK6-low versus CDK6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK6→partner) and Y-score (partner→CDK6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.201	+3.472	.007	.002	3	2
UCEC	STAT3_pY705 →	-0.329	-1.700	<.001	.040	3	2
UCEC	EGFR_pY1068 →	-0.223	-1.362	.012	.037	3	1
UCEC	FOXO3a_pS318_S321 →	-0.130	-2.492	.003	.001	3	1
UCEC	ACC1 →	+0.252	+2.183	.049	.033	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.373	+2.009	.037	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

eIF4E by CDK6 expression — UCEC

Explore this box plot interactively →