CDK6

Across TCGA cell cohorts, CDK6 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,388 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CDK6-associated GO terms across cancer lineages are Ventricular system development, Lateral ventricle development, and Negative regulation of monocyte differentiation. Each is linked with CDK6 in more than 13 cancer types. Because this analysis shows association rather than direction, both CDK6-to-partner and partner-to-CDK6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ventricular system development grouped by CDK6-low versus CDK6-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK6→partner) and Y-score (partner→CDK6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Ventricular system development →	+0.114	+0.898	<.001	.003	3	14
LIVER	Lateral ventricle development →	+0.190	+2.203	<.001	<.001	3	13
LUNG_SCLC	Negative regulation of monocyte differentiation →	+1.073	+1.930	.001	.001	3	12
BONE	Regulation of cell-matrix adhesion →	+0.147	+2.868	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Dentate gyrus development →	+0.216	+1.176	<.001	<.001	3	12
BONE	Positive regulation of cell-matrix adhesion →	+0.144	+2.464	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,388 associations by consensus.

Ventricular system development by CDK6 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →