CDK5RAP3

Across TCGA pan-cancer cohorts, CDK5RAP3 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated CDK5RAP3 data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher CDK5RAP3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CDK5RAP3 expression acts as an unfavorable survival marker, although some lineages such as COAD and CCRCC show a favorable association.

COAD, HNSC, and CCRCC are the cancer types where CDK5RAP3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	All	1.000	0.871	.034	24	view →
HNSC	OS	Median	IV	0.634	0.843	.017	7	view →
CCRCC	DFS	Quartile	II,III,IV	1.000	0.734	.031	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

CDK5RAP3–COAD (DFS)

Open the COAD breakdown →