CDK5RAP3

Across TCGA patient cohorts, CDK5RAP3 mutation is significantly associated with the RNA expression of many other genes, with 5,158 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDK5RAP3-associated genes across cancer lineages are ISCA1P2, RN7SL372P, and NDUFAF2P1. Each is linked with CDK5RAP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both CDK5RAP3-to-partner and partner-to-CDK5RAP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ISCA1P2 grouped by CDK5RAP3-low versus CDK5RAP3-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK5RAP3→partner) and Y-score (partner→CDK5RAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	ISCA1P2 →	+0.062	+3.684	.001	.005	3	3
BLCA	RN7SL372P →	+0.150	+4.112	<.001	.004	3	2
UCEC	NDUFAF2P1 →	+0.544	+2.324	<.001	.006	3	2
CESC	BMS1P9 →	+0.222	+4.091	<.001	.002	3	2
CESC	RNU6-1067P →	+0.211	+4.569	<.001	.005	3	2
CESC	LINC01758 →	+0.103	+4.231	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,158 associations by consensus.

ISCA1P2 by CDK5RAP3 expression — CESC

Explore this box plot interactively →