CDK5RAP3

Across TCGA patient cohorts, CDK5RAP3 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDK5RAP3-associated genes across cancer lineages are VHL, c-Met_pY1235, and ERCC1. Each is linked with CDK5RAP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both CDK5RAP3-to-partner and partner-to-CDK5RAP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by CDK5RAP3-low versus CDK5RAP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK5RAP3→partner) and Y-score (partner→CDK5RAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-1.175	-2.906	<.001	.001	3	3
UCEC	c-Met_pY1235 →	+0.060	+1.502	.028	.030	3	3
SKCM	ERCC1 →	-0.254	-3.000	.006	.035	3	2
UCEC	EGFR_pY1068 →	-0.234	-2.584	.011	.010	3	2
UCEC	STAT5a →	+0.416	+3.700	.004	.001	3	2
UCEC	ATM →	-0.414	-2.247	.013	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

VHL by CDK5RAP3 expression — UCEC

Explore this box plot interactively →