CDK5RAP3

Across TCGA cell cohorts, CDK5RAP3 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDK5RAP3-associated genes across cancer lineages are KRT25, TMCO5A, and SOX3. Each is linked with CDK5RAP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDK5RAP3-to-partner and partner-to-CDK5RAP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT25 grouped by CDK5RAP3-low versus CDK5RAP3-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK5RAP3→partner) and Y-score (partner→CDK5RAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	KRT25 →	+0.053	+5.087	<.001	.004	3	1
LARGE_INTESTINE	TMCO5A →	+0.019	+4.415	<.001	.007	3	1
BLOOD_Leukemia	SOX3 →	+0.021	+4.551	<.001	.004	3	1
LARGE_INTESTINE	ACSM6 →	+0.032	+4.169	<.001	.007	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

KRT25 by CDK5RAP3 expression — URINARY_TRACT

Explore this box plot interactively →