CDK5RAP1

Across TCGA pan-cancer cohorts, CDK5RAP1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated CDK5RAP1 data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher CDK5RAP1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CDK5RAP1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

LSCC, HNSC, and UCEC are the cancer types where CDK5RAP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.870	0.547	.002	26	view →
HNSC	OS	Tertile	III,IV	0.960	0.709	.002	22	view →
UCEC	OS	Quartile	All	1.000	0.882	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

CDK5RAP1–LSCC (DFS)

Open the LSCC breakdown →