CDK5RAP1

Across TCGA patient cohorts, CDK5RAP1 mutation is significantly associated with the RNA expression of many other genes, with 2,366 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDK5RAP1-associated genes across cancer lineages are TRMT112P7, MIR3689F, and PMM2P2. Each is linked with CDK5RAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDK5RAP1-to-partner and partner-to-CDK5RAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRMT112P7 grouped by CDK5RAP1-low versus CDK5RAP1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK5RAP1→partner) and Y-score (partner→CDK5RAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TRMT112P7 →	+0.066	+4.479	.003	.007	3	2
SKCM	MIR3689F →	+0.195	+3.732	<.001	.001	3	2
SKCM	PMM2P2 →	+0.026	+3.034	.001	.008	3	2
UCEC	PGP →	+0.550	+3.247	<.001	<.001	3	2
SKCM	RPL23AP82 →	+0.699	+3.591	<.001	.001	3	2
SKCM	LINC01357 →	-0.795	-3.430	.004	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,366 associations by consensus.

TRMT112P7 by CDK5RAP1 expression — BRCA

Explore this box plot interactively →