CDK5RAP1

Across TCGA patient cohorts, CDK5RAP1 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDK5RAP1-associated genes across cancer lineages are JNK_pT183_Y185, A-Raf_pS299, and FoxM1. Each is linked with CDK5RAP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CDK5RAP1-to-partner and partner-to-CDK5RAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by CDK5RAP1-low versus CDK5RAP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK5RAP1→partner) and Y-score (partner→CDK5RAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.180	-1.794	.009	.027	3	3
UCEC	A-Raf_pS299 →	-0.133	-2.584	.006	.010	3	2
UCEC	FoxM1 →	+0.237	+3.000	.026	.001	3	2
UCEC	MEK1 →	+0.430	+2.700	.004	.006	3	2
UCEC	Shc_pY317 →	-0.168	-1.807	.007	.027	3	2
UCEC	eIF4E →	+0.230	+3.013	.008	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

JNK_pT183_Y185 by CDK5RAP1 expression — UCEC

Explore this box plot interactively →