CDK5R1

Across TCGA patient cohorts, CDK5R1 protein abundance is significantly associated with the protein abundance of many other proteins, with 2,665 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDK5R1-associated proteins across cancer lineages are RPL23A_S43, KCTD8_S410, and ANK2. Each is linked with CDK5R1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDK5R1-to-partner and partner-to-CDK5R1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CDK5R1 versus RPL23A_S43 in GBM, with a Pearson correlation of -0.65.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK5R1→partner) and Y-score (partner→CDK5R1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPL23A_S43 →	-0.642	-0.656	.001	<.001	3	2
UCEC	KCTD8_S410 →	+1.379	+1.557	<.001	.001	3	2
UCEC	ANK2 →	+0.485	+1.170	.001	.002	3	1
UCEC	ANK2_S3765 →	+0.799	+1.289	<.001	<.001	3	1
UCEC	ANXA2_Y317 →	+0.533	+1.368	<.001	<.001	3	1
UCEC	APBA1 →	+0.871	+1.091	.002	<.001	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,665 associations by consensus.

CDK5R1 vs RPL23A_S43 — GBM

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