CDK5R1

Across TCGA patient cohorts, CDK5R1 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDK5R1-associated genes across cancer lineages are EGFR_pY1068, Notch1, and PCNA. Each is linked with CDK5R1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDK5R1-to-partner and partner-to-CDK5R1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CDK5R1-low versus CDK5R1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK5R1→partner) and Y-score (partner→CDK5R1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.264	-2.222	.004	.009	3	2
UCEC	Notch1 →	+0.154	+2.009	.003	.017	3	2
UCEC	PCNA →	+0.234	+2.000	.003	.029	3	2
UCEC	PDCD4 →	-0.540	-1.415	.002	.046	3	2
UCEC	14-3-3_beta →	-0.082	-3.295	.029	.009	3	1
UCEC	eIF4E →	+0.198	+3.183	.012	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

EGFR_pY1068 by CDK5R1 expression — UCEC

Explore this box plot interactively →