CDK5

Across TCGA pan-cancer cohorts, CDK5 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of CDK5’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CDK5 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types CDK5 is over-expressed in tumor.

COAD, LUAD, and HNSC are the cancer types where CDK5 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CDK5 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	+0.468	<.001	11	view →
LUAD	Female	II,III,IV	+0.385	<.001	9	view →
HNSC	Male	IV	+0.299	<.001	8	view →
LSCC	Male	II,III,IV	+0.338	<.001	7	view →
OV	All	All	+0.555	.023	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

CDK5–COAD

Open the COAD breakdown →