CDK4

Across TCGA patient cohorts, CDK4 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,622 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CDK4-associated proteins across cancer lineages are MCM3, KDM3A, and CDK1. Each is linked with CDK4 in more than 7 cancer types. Because this analysis shows association rather than direction, both CDK4-to-partner and partner-to-CDK4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CDK4 versus MCM3 in LUAD, with a Pearson correlation of 0.33.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK4→partner) and Y-score (partner→CDK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MCM3 →	+0.662	+0.550	<.001	<.001	3	8
LSCC	KDM3A →	+0.527	+0.632	<.001	<.001	3	8
LSCC	CDK1 →	+0.773	+0.721	<.001	<.001	3	7
BRCA	DNMT1 →	+0.453	+0.535	<.001	<.001	3	7
LUAD	MCM2 →	+0.886	+0.686	<.001	<.001	3	7
LSCC	MCM4 →	+0.601	+0.546	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,622 associations by consensus.

CDK4 vs MCM3 — LUAD

Explore this scatter interactively →