CDK4

Across TCGA patient cohorts, CDK4 protein abundance is significantly associated with the RNA expression of many other genes, with 7,534 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CDK4-associated genes across cancer lineages are CDKN2A, GIHCG, and H2AZ2. Each is linked with CDK4 in more than 4 cancer types. Because this analysis shows association rather than direction, both CDK4-to-partner and partner-to-CDK4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CDK4 versus CDKN2A in GBM, with a Pearson correlation of 0.58.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK4→partner) and Y-score (partner→CDK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CDKN2A →	+2.074	+0.699	<.001	<.001	3	5
GBM	GIHCG →	+0.719	+0.580	<.001	<.001	3	4
LSCC	H2AZ2 →	+0.533	+0.528	<.001	<.001	3	4
OV	CDKN2C →	+1.264	+0.491	<.001	<.001	3	4
GBM	TSFM →	+0.845	+0.652	<.001	<.001	3	4
GBM	CDKN2A-DT →	+0.910	+0.736	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,534 associations by consensus.

CDK4 vs CDKN2A — GBM

Explore this scatter interactively →