CDK4

Across TCGA patient cohorts, CDK4 protein abundance is significantly associated with the protein abundance of many other proteins, with 12,051 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible CDK4-associated proteins across cancer lineages are HDAC2, UPF1, and TRA2B. Each is linked with CDK4 in more than 4 cancer types. Because this analysis shows association rather than direction, both CDK4-to-partner and partner-to-CDK4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CDK4 versus HDAC2 in LSCC, with a Pearson correlation of 0.44.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK4→partner) and Y-score (partner→CDK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HDAC2 →	+0.364	+0.381	<.001	<.001	3	5
PDAC	UPF1 →	+0.204	+0.346	<.001	<.001	3	5
PDAC	TRA2B →	+0.387	+0.291	<.001	.003	3	5
HNSC	ACTL6A →	+0.316	+0.253	<.001	<.001	3	4
PDAC	STX4 →	-0.257	-0.229	<.001	<.001	3	4
OV	CDKN2A →	+0.944	+0.334	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,051 associations by consensus.

CDK4 vs HDAC2 — LSCC

Explore this scatter interactively →