CDK4

Across TCGA patient cohorts, CDK4 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDK4-associated genes across cancer lineages are EGFR_pY1068, ER-alpha_pS118, and ER-alpha. Each is linked with CDK4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDK4-to-partner and partner-to-CDK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CDK4-low versus CDK4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK4→partner) and Y-score (partner→CDK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.310	-3.321	.010	.010	3	1
UCEC	ER-alpha_pS118 →	-0.535	-3.584	.001	.002	3	1
UCEC	ER-alpha →	-1.388	-3.321	<.001	.010	3	1
UCEC	ACC_pS79 →	+0.503	+3.009	.002	.019	3	1
UCEC	p62 Lck ligand →	+0.446	+3.009	.004	.019	3	1
UCEC	PCNA →	+0.246	+2.459	.018	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

EGFR_pY1068 by CDK4 expression — UCEC

Explore this box plot interactively →