CDK4

Across TCGA cell cohorts, CDK4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,858 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible CDK4-associated GO terms across cancer lineages are Nucleolar large rRNA transcription by RNA polymerase I, DNA replication initiation, and Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Each is linked with CDK4 in more than 12 cancer types. Because this analysis shows association rather than direction, both CDK4-to-partner and partner-to-CDK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nucleolar large rRNA transcription by RNA polymerase I grouped by CDK4-low versus CDK4-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK4→partner) and Y-score (partner→CDK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Nucleolar large rRNA transcription by RNA polymerase I →	+0.118	+0.774	.002	.002	3	13
BLOOD_Myeloma	DNA replication initiation →	+0.159	+0.975	.002	.003	3	13
OVARY	Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.103	+0.776	<.001	.001	3	12
BLOOD_Lymphoma	Endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.149	+1.197	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	DNA strand elongation involved in DNA replication →	+0.165	+1.503	.003	.002	3	11
URINARY_TRACT	rRNA 5'-end processing →	+0.094	+0.579	.006	.009	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,858 associations by consensus.

Nucleolar large rRNA transcription by RNA polymerase I by CDK4 expression — LUNG_NSCLC_LUSC

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