CDK3

Across TCGA patient cohorts, CDK3 mutation is significantly associated with the RNA expression of many other genes, with 206 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDK3-associated genes across cancer lineages are RNA5SP500, AP5B1, and PRAMEF13. Each is linked with CDK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDK3-to-partner and partner-to-CDK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP500 grouped by CDK3-low versus CDK3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK3→partner) and Y-score (partner→CDK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNA5SP500 →	+0.316	+7.040	<.001	<.001	3	2
UCEC	AP5B1 →	+0.609	+3.218	.005	.009	3	2
UCEC	PRAMEF13 →	+0.032	+3.716	<.001	.002	3	2
SKCM	FN3K →	+1.174	+3.341	<.001	.005	3	2
SKCM	RN7SKP93 →	+0.092	+3.774	<.001	<.001	3	2
BLCA	RNA5SP390 →	+0.746	+6.018	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 206 associations by consensus.

RNA5SP500 by CDK3 expression — BLCA

Explore this box plot interactively →