CDK3

Across TCGA patient cohorts, CDK3 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDK3-associated genes across cancer lineages are eEF2, Gab2, and JNK2. Each is linked with CDK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDK3-to-partner and partner-to-CDK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by CDK3-low versus CDK3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK3→partner) and Y-score (partner→CDK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.449	+2.321	.012	.035	3	1
UCEC	Gab2 →	+0.533	+2.321	.002	.035	3	1
UCEC	JNK2 →	+0.361	+3.459	<.001	.005	3	1
UCEC	N-Ras →	-0.145	-3.446	.015	.005	3	1
UCEC	SF2 →	-0.133	-2.990	.015	.036	3	1
UCEC	TIGAR →	+0.243	+3.486	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

eEF2 by CDK3 expression — UCEC

Explore this box plot interactively →