CDK2

Across TCGA patient cohorts, CDK2 protein abundance is significantly associated with the RNA expression of many other genes, with 14,924 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CDK2-associated genes across cancer lineages are MCM4, KIF18A, and HJURP. Each is linked with CDK2 in more than 8 cancer types. Because this analysis shows association rather than direction, both CDK2-to-partner and partner-to-CDK2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CDK2 versus MCM4 in LUAD, with a Pearson correlation of 0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK2→partner) and Y-score (partner→CDK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MCM4 →	+0.947	+0.322	<.001	<.001	3	9
BRCA	KIF18A →	+0.998	+0.391	<.001	<.001	3	9
BRCA	HJURP →	+1.108	+0.382	<.001	<.001	3	9
LUAD	KIF23 →	+1.054	+0.303	<.001	<.001	3	9
GBM	CCNA2 →	+1.126	+0.519	<.001	<.001	3	9
UCEC	CHEK1 →	+0.898	+0.357	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,924 associations by consensus.

CDK2 vs MCM4 — LUAD

Explore this scatter interactively →