CDK2

Across TCGA cell cohorts, CDK2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,267 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CDK2-associated GO terms across cancer lineages are Cell cycle DNA replication, Negative regulation of cell cycle process, and Positive regulation of chromosome condensation. Each is linked with CDK2 in more than 18 cancer types. Because this analysis shows association rather than direction, both CDK2-to-partner and partner-to-CDK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cell cycle DNA replication grouped by CDK2-low versus CDK2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK2→partner) and Y-score (partner→CDK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Cell cycle DNA replication →	+0.119	+1.235	.003	.001	3	19
BONE	Negative regulation of cell cycle process →	+0.094	+1.278	.003	<.001	3	18
BLOOD_Myeloma	Positive regulation of chromosome condensation →	+0.252	+1.563	<.001	<.001	3	18
KIDNEY	Nuclear division →	+0.085	+0.881	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Nuclear DNA replication →	+0.117	+1.169	.003	.002	3	18
UPPER_AERODIGESTIVE_TRACT	DNA strand elongation involved in DNA replication →	+0.173	+1.464	.002	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,267 associations by consensus.

Cell cycle DNA replication by CDK2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →