CDK19

Across TCGA patient cohorts, CDK19 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDK19-associated genes across cancer lineages are A-Raf_pS299, Heregulin, and MEK1. Each is linked with CDK19 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDK19-to-partner and partner-to-CDK19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by CDK19-low versus CDK19-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK19→partner) and Y-score (partner→CDK19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.118	-1.700	.005	.042	3	2
UCEC	Heregulin →	-0.127	-2.102	.003	.016	3	2
UCEC	MEK1 →	+0.500	+3.807	<.001	<.001	3	2
UCEC	MSH2 →	-0.325	-2.089	<.001	.016	3	2
UCEC	N-Ras →	-0.100	-2.680	.017	.006	3	2
UCEC	ATM →	-0.647	-3.893	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

A-Raf_pS299 by CDK19 expression — UCEC

Explore this box plot interactively →