CDK19

Across TCGA cell cohorts, CDK19 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDK19-associated genes across cancer lineages are OR8H2, DPRX, and MTRNR2L10. Each is linked with CDK19 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDK19-to-partner and partner-to-CDK19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8H2 grouped by CDK19-low versus CDK19-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK19→partner) and Y-score (partner→CDK19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR8H2 →	+0.023	+6.357	<.001	<.001	3	1
CNS	DPRX →	+0.068	+5.321	<.001	.005	3	1
CNS	MTRNR2L10 →	+0.016	+6.357	<.001	<.001	3	1
LARGE_INTESTINE	SH3GL2 →	+1.159	+3.252	.003	.009	3	1
LARGE_INTESTINE	PTH2R →	+0.851	+2.716	<.001	.009	3	1
LARGE_INTESTINE	TECRL →	+0.011	+3.240	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

OR8H2 by CDK19 expression — CNS

Explore this box plot interactively →