CDK18

Across TCGA patient cohorts, CDK18 mutation is significantly associated with the RNA expression of many other genes, with 4,287 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDK18-associated genes across cancer lineages are RNA5SP411, NUDT5, and DNAJC7. Each is linked with CDK18 in more than 2 cancer types. Because this analysis shows association rather than direction, both CDK18-to-partner and partner-to-CDK18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP411 grouped by CDK18-low versus CDK18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK18→partner) and Y-score (partner→CDK18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP411 →	+1.042	+1.765	<.001	.001	3	3
SKCM	NUDT5 →	+0.393	+2.176	.002	.002	3	3
UCEC	DNAJC7 →	+0.425	+1.874	<.001	.002	3	3
SKCM	PSMD14 →	+0.517	+2.176	.002	.002	3	3
SKCM	POMP →	+0.383	+2.739	.001	.003	3	3
UCEC	CCL5 →	+0.990	+2.223	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,287 associations by consensus.

RNA5SP411 by CDK18 expression — UCEC

Explore this box plot interactively →