CDK18

Across TCGA patient cohorts, CDK18 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDK18-associated genes across cancer lineages are Src_pY527, Caspase-7-cleavedD198, and c-Kit. Each is linked with CDK18 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDK18-to-partner and partner-to-CDK18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Src_pY527 grouped by CDK18-low versus CDK18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK18→partner) and Y-score (partner→CDK18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Src_pY527 →	-0.419	-2.311	.005	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.785	+3.807	<.001	<.001	3	2
UCEC	c-Kit →	-0.176	-1.662	.032	.011	3	2
UCEC	14-3-3_beta →	-0.078	-2.088	.027	.016	3	1
UCEC	eEF2 →	+0.343	+1.362	.006	.037	3	1
UCEC	EGFR_pY1068 →	-0.321	-2.584	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

Src_pY527 by CDK18 expression — UCEC

Explore this box plot interactively →