CDK17

Across TCGA patient cohorts, CDK17 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDK17-associated genes across cancer lineages are Caspase-7-cleavedD198, 4E-BP1, and Di-Ras3. Each is linked with CDK17 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDK17-to-partner and partner-to-CDK17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CDK17-low versus CDK17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK17→partner) and Y-score (partner→CDK17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.516	+1.785	.005	.007	3	2
UCEC	4E-BP1 →	+0.318	+2.906	<.001	.001	3	2
UCEC	Di-Ras3 →	-0.091	-1.794	.048	.024	3	2
UCEC	eIF4E →	+0.145	+2.000	.027	.009	3	1
UCEC	ERK2 →	+0.163	+1.999	.006	.008	3	1
UCEC	IGFBP2 →	-0.605	-2.700	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Caspase-7-cleavedD198 by CDK17 expression — UCEC

Explore this box plot interactively →