CDK16

Across TCGA patient cohorts, CDK16 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDK16-associated genes across cancer lineages are Bak, Caspase-7-cleavedD198, and 4E-BP1. Each is linked with CDK16 in more than 2 cancer types. Because this analysis shows association rather than direction, both CDK16-to-partner and partner-to-CDK16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bak grouped by CDK16-low versus CDK16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK16→partner) and Y-score (partner→CDK16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Bak →	+0.226	+2.222	.009	.009	3	3
COAD	Caspase-7-cleavedD198 →	+0.913	+2.815	.035	.036	3	2
UCEC	4E-BP1 →	+0.411	+2.459	<.001	<.001	3	2
UCEC	GATA6 →	-0.128	-3.307	.021	.009	3	2
UCEC	INPP4B →	-0.252	-2.115	.024	.016	3	2
UCEC	MEK1 →	+0.367	+2.584	.003	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

Bak by CDK16 expression — UCEC

Explore this box plot interactively →