CDK14

Across TCGA patient cohorts, CDK14 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDK14-associated genes across cancer lineages are ASNS, eIF4E, and Cyclin-B1. Each is linked with CDK14 in more than 2 cancer types. Because this analysis shows association rather than direction, both CDK14-to-partner and partner-to-CDK14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by CDK14-low versus CDK14-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK14→partner) and Y-score (partner→CDK14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.713	+2.815	.001	.036	3	2
UCEC	eIF4E →	+0.167	+2.115	.025	.017	2	3
UCEC	Cyclin-B1 →	+0.545	+1.662	.005	.011	3	2
SKCM	MSH2 →	+0.367	+2.824	.006	.036	3	1
COAD	SCD →	+0.175	+2.849	.021	.034	3	1
UCEC	14-3-3_beta →	-0.092	-2.088	.009	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

ASNS by CDK14 expression — COAD

Explore this box plot interactively →