CDK13

Across TCGA pan-cancer cohorts, CDK13 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CDK13 data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CDK13 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CDK13 expression acts as an unfavorable survival marker, although some lineages such as GBM and LUAD show a favorable association.

HNSC, GBM, and LUAD are the cancer types where CDK13 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	IV	0.438	0.940	<.001	52	view →
GBM	OS	Tertile	All	0.542	0.258	.002	11	view →
LUAD	OS	Tertile	II,III,IV	1.000	0.916	.034	4	view →
CCRCC	OS	Quartile	All	0.417	1.000	.015	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CDK13–HNSC (DFS)

Open the HNSC breakdown →