CDK13

Across TCGA patient cohorts, CDK13 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDK13-associated genes across cancer lineages are eEF2, 4E-BP1, and Caspase-8. Each is linked with CDK13 in more than 2 cancer types. Because this analysis shows association rather than direction, both CDK13-to-partner and partner-to-CDK13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by CDK13-low versus CDK13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK13→partner) and Y-score (partner→CDK13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.300	+1.321	.005	.012	3	3
UCEC	4E-BP1 →	+0.304	+3.999	<.001	<.001	3	3
UCEC	Caspase-8 →	-0.227	-1.999	.002	<.001	3	2
SKCM	Caveolin-1 →	-0.942	-3.169	.005	.019	3	2
UCEC	eIF4E →	+0.211	+3.013	<.001	<.001	3	2
UCEC	GAPDH →	+0.427	+1.906	.008	.014	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

eEF2 by CDK13 expression — UCEC

Explore this box plot interactively →