CDK12

Across TCGA pan-cancer cohorts, CDK12 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CDK12 data layer compared with 26 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher CDK12 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CDK12 expression acts as an unfavorable survival marker, although some lineages such as COAD and LUAD show a favorable association.

COAD, HNSC, and CCRCC are the cancer types where CDK12 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.887	.020	24	view →
HNSC	OS	Tertile	All	0.347	1.000	.018	13	view →
CCRCC	OS	Median	All	0.886	1.000	.002	12	view →
LUAD	DFS	Median	III,IV	0.928	0.553	.011	8	view →
LSCC	OS	Quartile	II,III,IV	1.000	0.674	.032	5	view →
PDAC	DFS	Median	II,III,IV	0.889	0.669	.017	3	view →
GBM	DFS	Median	All	0.286	0.439	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CDK12–COAD (DFS)

Open the COAD breakdown →