CDK12

Across TCGA patient cohorts, CDK12 RNA expression is significantly associated with the RNA expression of many other genes, with 21,257 significant associations in total. ACC shows the largest number of these associations.

The most reproducible CDK12-associated genes across cancer lineages are ZNF180, SMG8, and ANKRD11. Each is linked with CDK12 in more than 33 cancer types. Because this analysis shows association rather than direction, both CDK12-to-partner and partner-to-CDK12 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CDK12 versus ZNF180 in UVM, with a Pearson correlation of 0.71.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK12→partner) and Y-score (partner→CDK12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	ZNF180 →	+0.949	+0.751	<.001	<.001	3	34
DLBC	SMG8 →	+1.645	+1.286	<.001	<.001	3	34
SCLC	ANKRD11 →	+1.212	+0.660	<.001	<.001	3	34
SCLC	RSKR →	+1.204	+0.726	<.001	<.001	3	34
DLBC	KMT2D →	+1.836	+1.261	<.001	<.001	3	34
UVM	ZNF146 →	+1.386	+0.852	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,257 associations by consensus.

CDK12 vs ZNF180 — UVM

Explore this scatter interactively →